Patients with carotid intraplaque hemorrhage have higher incidence of cerebral microbleeds

Abstract Background Carotid intraplaque hemorrhage (IPH) is considered a strong marker of histologically defined plaque vulnerability leading to cerebrovascular ischemic events. Cerebral microbleeds (CMBs) represent hemorrhage-prone small vessel disease and they are common finding on brain MRI in patients with disease. However, the potential mechanism risk for CMBs not clear. The characteristics carotid lesions have been relevant relationship between artery atherosclerosis presence CMBs. association IPH has investigated yet. Purpose We previously reported prevalence non-obstructive who underwent endarterectomy (CEA). In this study, we aimed investigate whether extent related existence hypothesized that would higher Methods This retrospective study enrolled 101 consecutive undergoing CEA symptomatic (including stroke, TIA, amaurosis fugax) or asymptomatic ipsilateral specimens were collected at from all stained Movat Pentachrome identify (%) IPH. Neck CTA was obtained measure degree stenosis. Brain pre-surgically performed studied using T2*-weighted gradient-recalled echo (GRE) susceptibility-weighted imaging (SWI) sequence. counted localized. Clinical biochemical data, comorbidities, medications recorded. examined adjusted other factors. Results 57 (56.4%) patients. more observed compared those without [19 (33.3%) vs 5 (11.4%); p=0.010]. Logistic regression analysis demonstrated an atheroma [OR 1.051 (95% CI 1.012–1.090); p=0.009]. Moreover, associated number (p=0.004). CMBs, median stenosis 40% (35–65%) it 70% (50–80%) significant difference two groups (p=0.049). Conclusions CEA, its MR imaging. may be events atherosclerotic can distinguish severity Funding Acknowledgement Type funding sources: Other. Main source(s): Mayo Clinic Foundation